Single-cell analysis of adaptive NK and CMV-specific T-cell dynamics after allogeneic HSCT∗
Aino-Elina Häkkinen, Jani Huuhtanen, Sofie Lundgren, Riitta Niittyvuopio, Urpu Salmenniemi, Harri Lähdesmäki, Mikko A. I. Keränen, Mikko Myllymäki, Satu Mustjoki · 2026
Read Single-cell analysis of adaptive NK and CMV-specific T-cell dynamics after allogeneic HSCT∗ by Aino-Elina Häkkinen, Jani Huuhtanen, Sofie Lundgren, Riitta Niittyvuopio, Urpu Salmenniemi, Harri Lähdesmäki, Mikko A. I. Keränen, Mikko Myllymäki, Satu Mustjoki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13528388.txt.
Description
Aino-Elina Häkkinen and co-authors profile immune recovery cell by cell after stem cell transplants in a 2026 study. A virus called CMV often wakes after transplant and reshapes the rebuilding immune system. The team read single-cell gene activity and receptor codes in blood from donor-recipient pairs across the first three months.
Thirty-two sample sets were profiled. Monocytes rose first, then T cells and natural killer cells. Some patient CD4 cells persisted in the mix. Virus-specific T cells and adaptive killer cells matured more slowly when the donor had never met the virus. Adaptive killer cells from exposed donors matured fast and recalled well, yet killed less strongly. Some virus-fighting T cell clones swelled to over sixty percent of their class.
Catalog record
| CREATOR | Aino-Elina Häkkinen, Jani Huuhtanen, Sofie Lundgren, Riitta Niittyvuopio, Urpu Salmenniemi, Harri Lähdesmäki, Mikko A. I. Keränen, Mikko Myllymäki, Satu Mustjoki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |