Oxidative stress and cancer: current insights and therapeutic implications
María Escribano-Cebrián, Marina Bataller, Marc Biasini, Yoelsis García-Mayea, David Virós, Matilde E. LLeonart · 2026
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Description
María Escribano-Cebrián and co-authors review the double role of oxidative stress in cancer in a 2026 paper. The stress arises when reactive oxygen species outrun antioxidant defenses, and its effect depends on dose and context.
Small to moderate amounts switch on growth pathways and mute tumor suppressors, feeding tumors and drug resistance. Large amounts wreck the genome and kill cells. Reactive species also reshape the tumor neighborhood, aiding new blood vessels, spread, and immune suppression. Cancer stem cells keep their levels low to survive and seed relapse. This duality shapes therapy: pro-oxidant drugs try to overwhelm tumor defenses, while antioxidant tactics guard normal tissue. Dose and timing decide friend from foe.
Catalog record
| CREATOR | María Escribano-Cebrián, Marina Bataller, Marc Biasini, Yoelsis García-Mayea, David Virós, Matilde E. LLeonart |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 117 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |