Role and prognostic value of N6-methyladenosine RNA modification regulators in glycolytic reprogramming during sepsis
Xia Liu, Yanyu Zhang, Lei Feng, Aruna Xiang, Zhuqing Kang, Qi Zhang, Lei Kang · 2026
Read Role and prognostic value of N6-methyladenosine RNA modification regulators in glycolytic reprogramming during sepsis by Xia Liu, Yanyu Zhang, Lei Feng, Aruna Xiang, Zhuqing Kang, Qi Zhang, Lei Kang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13528130.txt.
Description
Liu and colleagues published a 2026 study on RNA tags that track with sepsis severity. Sepsis is a runaway body response to infection that can kill quickly. Cells also rewire sugar burning during sepsis, a shift tied to outcomes. The team pooled several sepsis datasets to map RNA-tag regulators.
Most tag regulators ran lower in sepsis patients than in healthy people. Two reader proteins ran higher, standing out from the general fall. One eraser protein, ALKBH5, tracked closely with sugar-burning activity levels. Its removal in lab models shifted many of the same genes as sepsis. A risk model built on these regulators may help forecast outcomes. One validation set agreed with the model's calls nearly nine times in ten.
Catalog record
| CREATOR | Xia Liu, Yanyu Zhang, Lei Feng, Aruna Xiang, Zhuqing Kang, Qi Zhang, Lei Kang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |