Dysregulation of GDNF and GFRα1 expression in multifactorial Hirschsprung disease
Gunadi, Setiani Silvy Nurhidayah, Aleyy Adany, Farah Shahnaz Pravinovia, Siti Maisaroh, Kurnia Corie Tonda, Pramana Adhityo, Estelita Liana, Kristy Iskandar, Andi Dwihantoro · 2026
Read Dysregulation of GDNF and GFRα1 expression in multifactorial Hirschsprung disease by Gunadi, Setiani Silvy Nurhidayah, Aleyy Adany, Farah Shahnaz Pravinovia, Siti Maisaroh, Kurnia Corie Tonda, Pramana Adhityo, Estelita Liana, Kristy Iskandar, Andi Dwihantoro (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13528072.txt.
Description
Gunadi and nine colleagues measure two growth signals in colon tissue from children with Hirschsprung disease in a 2026 study. The disease leaves part of the colon without nerve ganglia, blocking stool passage. The signals, called GDNF and GFRα1, guide nerve cell growth before birth. Known gene faults explain only about eighty percent of cases. The team used PCR tests on tissue with and without ganglia, plus healthy controls.
Both signals were far more active in patient tissue than in controls. GDNF ran over two hundred times higher in the ganglion-bearing part. The receptor GFRα1 rose roughly thirty-fold there. Segments without ganglia also showed big rises. The two patient segments did not differ from each other. The authors read this as a system-wide mis-set, not a local one. They call for work on how the whole network goes wrong.
Catalog record
| CREATOR | Gunadi, Setiani Silvy Nurhidayah, Aleyy Adany, Farah Shahnaz Pravinovia, Siti Maisaroh, Kurnia Corie Tonda, Pramana Adhityo, Estelita Liana, Kristy Iskandar, Andi Dwihantoro |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15758 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |