Novel approaches to modulate CAR-T cell function by targeting the tumor microenvironment in ovarian cancer
Saber SamadiAfshar, Hossein Azizi, Meghdad Yeganeh, Sahel SamadiAfshar, Thomas Skutella · 2026
Read Novel approaches to modulate CAR-T cell function by targeting the tumor microenvironment in ovarian cancer by Saber SamadiAfshar, Hossein Azizi, Meghdad Yeganeh, Sahel SamadiAfshar, Thomas Skutella (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13527969.txt.
Description
Saber SamadiAfshar and four colleagues review in 2026 why CAR-T cell therapy struggles against ovarian cancer. CAR-T cells are a patient's own immune cells, engineered to hunt cancer. The approach transformed care for blood cancers. Ovarian tumors, though, sit inside a suppressive neighborhood of cells and signals called the tumor microenvironment. Five-year survival for advanced disease is only about thirty percent.
The review maps how that environment blocks CAR-T cells from entering tumors, lasting, and killing. It then weighs new strategies: redesigned receptors, drug combinations, and tools that remodel the tumor surroundings. The authors frame the work as a roadmap. Their aim is to move CAR-T therapy from promise toward routine use in this hard-to-treat cancer.
Catalog record
| CREATOR | Saber SamadiAfshar, Hossein Azizi, Meghdad Yeganeh, Sahel SamadiAfshar, Thomas Skutella |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61169 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |