pH-responsive in situ antigen capture and cytosolic delivery synergize to elicit robust systemic antitumor immunity
Zhuoling Bi, Shucheng Zhang, Guanyu Jin, Zhaofan Yang, Shanyi Lin, Lanqing Wang, Bingzheng Yu, Luyao Wang, Yuanzhen Su, Sijun Xiang, Xinyu Xiang, Letian Lv, Tianlin Lao, Jianfeng Zhou, Shixian Lv, Xiaozhi Rong · 2026
Read pH-responsive in situ antigen capture and cytosolic delivery synergize to elicit robust systemic antitumor immunity by Zhuoling Bi, Shucheng Zhang, Guanyu Jin, Zhaofan Yang, Shanyi Lin, Lanqing Wang, Bingzheng Yu, Luyao Wang, Yuanzhen Su, Sijun Xiang, Xinyu Xiang, Letian Lv, Tianlin Lao, Jianfeng Zhou, Shixian Lv, Xiaozhi Rong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13527964.txt.
Description
Zhuoling Bi and fifteen colleagues describe a 2026 gel-based cancer vaccine tested in mice. The idea is to turn a patient's own tumor into the vaccine source. A hydrogel placed at the surgery site holds two agents. One is doxorubicin, a chemotherapy drug that kills tumor cells in a way that alerts the immune system. The other is a charged polymer that grabs the released tumor proteins.
The polymer also helps those proteins escape inside immune cells, where they can be presented to T cells. Lab tests showed stronger dendritic cell maturation and antigen display. In mouse models of breast tumor recurrence, treated animals resisted both regrowth and tumors on the opposite side. Memory T cell responses rose as well. The authors see a flexible route to personalized immunotherapy.
Catalog record
| CREATOR | Zhuoling Bi, Shucheng Zhang, Guanyu Jin, Zhaofan Yang, Shanyi Lin, Lanqing Wang, Bingzheng Yu, Luyao Wang, Yuanzhen Su, Sijun Xiang, Xinyu Xiang, Letian Lv, Tianlin Lao, Jianfeng Zhou, Shixian Lv, Xiaozhi Rong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63736 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |