Serum FAP⁺ exosome-based flow cytometric detection: potential utility in early diagnosis, disease progression assessment, and surgical response monitoring of lung adenocarcinoma
Ming Liu, Xiamin He, Jing Chen, Juan Huang, Xiang Lv, Guanghua Liu, Yijing Cai, Yanhui Lin, Yaocheng Wang, Yingying Cao, Minjian Huang, Rongzhao Zhang, Lilan Zhao, Jianlin Chen, Chundong Yu, Hao Zhang, Fangqin Xue, Yi Huang · 2026
Read Serum FAP⁺ exosome-based flow cytometric detection: potential utility in early diagnosis, disease progression assessment, and surgical response monitoring of lung adenocarcinoma by Ming Liu, Xiamin He, Jing Chen, Juan Huang, Xiang Lv, Guanghua Liu, Yijing Cai, Yanhui Lin, Yaocheng Wang, Yingying Cao, Minjian Huang, Rongzhao Zhang, Lilan Zhao, Jianlin Chen, Chundong Yu, Hao Zhang, Fangqin Xue, Yi Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13527904.txt.
Description
Ming Liu leads a large team reporting in 2026 on a blood test idea for lung adenocarcinoma, the most common form of lung cancer. The test measures tiny particles called exosomes that carry fibroblast activation protein, a marker found on fibroblasts that support tumor growth. The group built a flow cytometry assay, a method that counts tagged particles passing through a laser beam.
Exosomes from cancer-associated fibroblasts carried extra amounts of the protein, linked to the surface marker CD9. In patients, blood levels were higher than in healthy donors or people with harmless lung lesions, and levels rose with cancer stage. For early-stage disease the assay reached an area under the curve of 0.932, beating standard markers such as CEA, and levels fell after surgery.
Catalog record
| CREATOR | Ming Liu, Xiamin He, Jing Chen, Juan Huang, Xiang Lv, Guanghua Liu, Yijing Cai, Yanhui Lin, Yaocheng Wang, Yingying Cao, Minjian Huang, Rongzhao Zhang, Lilan Zhao, Jianlin Chen, Chundong Yu, Hao Zhang, Fangqin Xue, Yi Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44147 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |