Uncovering common pathways and potential drug targets in COVID-19 and venous thrombosis via systems biology approaches
Boyang Yu, Rongjian Gao, Wenchao Ma · 2026
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Description
Boyang Yu and colleagues hunted for shared molecular roots of COVID-19 and venous blood clots. Published in 2026, the systems biology study mined five public gene-expression datasets, comparing patients with COVID-19 and clotting disorders against controls. Clots complicate many COVID-19 cases and raise death risk, yet common pathways were poorly mapped.
Two genes stood out: SELP and CLEC4D, both tied to immune control and clot formation, with higher expression in certain immune cells confirmed by lab tests and animal models. Network analyses mapped their regulators, and drug-sensitivity checks linked them to specific chemotherapy agents. The authors propose both genes as markers and treatment targets for the two conditions jointly. Readers get a data-driven bridge between infection, immunity, and clotting.
Catalog record
| CREATOR | Boyang Yu, Rongjian Gao, Wenchao Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |