HE4: a potential diagnostic biomarker in autoimmune diseases
Qinni Yang · 2026
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Description
Qinni Yang reviewed a protein best known in ovarian cancer as a possible marker for autoimmune disease. Published in 2026, the single-author review covers human epididymal protein 4, or HE4, a secreted protein that tracks ovarian cancer with better accuracy than older markers. Cancer and autoimmune disease share overactive immunity and inflammation, raising the question of whether HE4 also tracks autoimmunity.
Evidence links HE4 to lupus, Sjögren syndrome, rheumatoid arthritis with lung disease, and IgA nephropathy, with levels reflecting disease severity. The review walks through HE4 biology in these conditions and weighs its promise for diagnosis and monitoring of chronic inflammatory autoimmune disease. Readers get a candidate marker with a plausible mechanism, still needing prospective validation before clinical use.
Catalog record
| CREATOR | Qinni Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |