Glutaminolysis as a metabolic checkpoint of protective Th1/Th17 immunity against Mycobacterium tuberculosis
Urszula Radzikowska, Sylwia Smolińska, Marlena Tynecka, Andrzej Eljaszewicz · 2026
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Description
Urszula Radzikowska and others comment, in a 2026 editorial, on new evidence that glutamine breakdown acts as a metabolic checkpoint for protective immunity against tuberculosis. The discussed study found the enzyme GLS1, which starts glutaminolysis, raised in blood cells from patients with active tuberculosis and rising further after bacterial stimulation.
Blocking the enzyme in that study weakened the Th1 and Th17 helper T-cell responses that defend against the bacterium. It also cut energy production and let bacteria survive better inside macrophages. The effect was traced to histone marks maintained by a GLS1-derived metabolite and reversible with supplements. The editorialists stress context. The same checkpoint drives harmful responses in autoimmune disease, where blocking helps, yet sustains protective responses in tuberculosis, where blocking harms, shaping how future GLS1 drugs should be judged.
Catalog record
| CREATOR | Urszula Radzikowska, Sylwia Smolińska, Marlena Tynecka, Andrzej Eljaszewicz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |