Eruptive gouty panniculitis associated with idiopathic multicentric Castleman disease (iMCD-NOS)
Max Wu, Karen Koch, Doug White, Duncan Lamont · 2026
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Description
Wu and colleagues present a 2026 case report linking an outbreak of gouty panniculitis, urate crystals inflaming the fat under the skin, with a rare immune disorder. The patient, a 42-year-old Pacific Islander man, developed the skin eruption as idiopathic multicentric Castleman disease began, . A lymph node biopsy confirmed the diagnosis.
He responded well to siltuximab, a drug that blocks the immune signal interleukin-6, a known driver of this disease. Gout in fat tissue is rare on its own; an eruptive case arriving with systemic illness should prompt a search for a hidden blood or immune disorder, the authors argue. The exact link between the two conditions remains unclear. The case adds a visible skin clue to the early picture of a dangerous, hard-to-spot disease.
Catalog record
| CREATOR | Max Wu, Karen Koch, Doug White, Duncan Lamont |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |