Loss of OXGR1 function uncouples intrarenal RAS activation from pendrin and αENaC regulation and blunts angiotensin II-induced hypertension
Pilar Cárdenas, Juan Castillo-Geraldo, Lilian Caroline Gonçalves de Oliveira, Nicolas Muñoz, Rodrigo Yokota, Marina de Moura Bello, Gabriel Joo-Mulsow, Luis Michea, Dulce Elena Casarini, Alexis A. Gonzalez · 2026
Read Loss of OXGR1 function uncouples intrarenal RAS activation from pendrin and αENaC regulation and blunts angiotensin II-induced hypertension by Pilar Cárdenas, Juan Castillo-Geraldo, Lilian Caroline Gonçalves de Oliveira, Nicolas Muñoz, Rodrigo Yokota, Marina de Moura Bello, Gabriel Joo-Mulsow, Luis Michea, Dulce Elena Casarini, Alexis A. Gonzalez (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13527438.txt.
Description
Cárdenas and a team of colleagues showed that a kidney receptor is required for hormone-driven high blood pressure in twenty twenty-six. The kidneys' own renin-angiotensin system promotes sodium retention. In the collecting duct, a signal molecule from metabolism, acting through the receptor OXGR1, was suspected of coordinating sodium transport across two cell types.
Mice received two weeks of angiotensin two infusion, with the receptor either blocked by a drug or deleted genetically. Normal mice developed higher blood pressure, retained sodium, and raised the transport proteins pendrin and alpha ENaC. Mice without working OXGR1 were protected on all counts: blunted pressure rise, less retention, and no rise in the transport proteins or local hormone activity. The authors identify OXGR1 as the coupling link and a possible drug target.
Catalog record
| CREATOR | Pilar Cárdenas, Juan Castillo-Geraldo, Lilian Caroline Gonçalves de Oliveira, Nicolas Muñoz, Rodrigo Yokota, Marina de Moura Bello, Gabriel Joo-Mulsow, Luis Michea, Dulce Elena Casarini, Alexis A. Gonzalez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |