Molecular Characterization of DENV‐1 Isolates From Pakistan Reveals Immunogenic Variability and Antiviral Potential of Phytochemicals Targeting the CprM Region
Sajid Ali Shah, Syed Ahsan Shahid, Sidra Rahman, Muhammad Ali · 2026
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Description
Shah and co-authors profile dengue virus samples from Pakistan and screen plant compounds against them in this 2026 study. Dengue infects about 390 million people a year worldwide. Pakistan hosts four established serotypes, and no effective antiviral drug exists.
The team screened 45 patient samples from Peshawar, finding the highest infection rate, 49 percent, in people aged 20 to 40. Six isolates grouped with the DENV-1 family near strains from China, India, and Bangladesh. Several amino acid changes in the virus's coat region may affect how the immune system sees it. The team then docked 60 plant compounds against that region. Nine bound strongly with good safety profiles.
Catalog record
| CREATOR | Sajid Ali Shah, Syed Ahsan Shahid, Sidra Rahman, Muhammad Ali |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |