Metabolic Reprogramming of NSUN2-Mediated m5C Modification Promotes the Progression of Hepatocellular Carcinoma by Restricting Natural Killer Cell-Mediated Cytotoxicity
Shengwei Mao, Yuan Fang, Jun Gao, Jiafeng Chen, Zhiqi Guan, Xuhui Zhao, Jinglei Wu, Xiaoling Wu, Guiqi Zhu, Xiangyu Zhang, Qianfu Zhao, Rui Yang, Yi Wang, Tianhao Chu, Yichao Bu, Jialu Fu, Hongxu Li, Zheng Tang, Yinghong Shi, Jian Zhou, Jia Fan, Jinling Jiang, Weiren Liu · 2026
Read Metabolic Reprogramming of NSUN2-Mediated m5C Modification Promotes the Progression of Hepatocellular Carcinoma by Restricting Natural Killer Cell-Mediated Cytotoxicity by Shengwei Mao, Yuan Fang, Jun Gao, Jiafeng Chen, Zhiqi Guan, Xuhui Zhao, Jinglei Wu, Xiaoling Wu, Guiqi Zhu, Xiangyu Zhang, Qianfu Zhao, Rui Yang, Yi Wang, Tianhao Chu, Yichao Bu, Jialu Fu, Hongxu Li, Zheng Tang, Yinghong Shi, Jian Zhou, Jia Fan, Jinling Jiang, Weiren Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13527209.txt.
Description
Shengwei Mao and co-authors trace how a liver cancer enzyme helps tumors hide from natural killer cells in a 2026 study. Liver cancer resists immune therapy, and killer cells that do enter tumors often lose their punch. A gene hunt in cancer cells grown with killer cells pointed to one enzyme as a suppressor.
The enzyme places chemical marks on RNA and rewires the cell's metabolism. The team mapped those marks and the gene activity and chromatin changes that follow, including effects on a key immune checkpoint. Blocking the enzyme in dish and animal tests restored killer cell attack. Patient tissue and outcome data backed the link. The work nominates the enzyme as a drug target for combination therapy.
Catalog record
| CREATOR | Shengwei Mao, Yuan Fang, Jun Gao, Jiafeng Chen, Zhiqi Guan, Xuhui Zhao, Jinglei Wu, Xiaoling Wu, Guiqi Zhu, Xiangyu Zhang, Qianfu Zhao, Rui Yang, Yi Wang, Tianhao Chu, Yichao Bu, Jialu Fu, Hongxu Li, Zheng Tang, Yinghong Shi, Jian Zhou, Jia Fan, Jinling Jiang, Weiren Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |