Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio · 2026
Read Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis by Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13527182.txt.
Description
Giammarco Milella and five co-authors model how ALS disability unfolds in a 2026 paper. ALS steals movement step by step, but the order differs by person. A data driven method called SuStaIn can infer subtypes and stages. The team fed it item scores from a standard function scale.
Records came from over eight hundred trial participants. The method found three early patterns: fine hand skills, gross movement, and speech and swallowing. Each subtype had its own ordered chain of losses. Stage labels stayed stable across thousands of follow up visits. An outside group of patients confirmed the same ordering. Higher stage at the start meant higher risk of death. The model could help trials group patients more fairly.
Catalog record
| CREATOR | Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |