Skeletal restructuring of oxetanes through photoinduced oxygen deletion
Ying-Qi Zhang, Shuo-Han Li, Ming Joo Koh · 2026
Read Skeletal restructuring of oxetanes through photoinduced oxygen deletion by Ying-Qi Zhang, Shuo-Han Li, Ming Joo Koh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13527086.txt.
Description
Zhang, Li, and Koh published a 2026 study on deleting one atom to rebuild ring molecules. Oxetanes are four-sided rings with one oxygen, prized in drug design. Pulling the oxygen out shrinks or reshapes the ring in one stroke. The team used light and iodoform, with no catalyst, for the cut.
The reaction first opened the ring into a two-iodine chain piece. That piece then closed into three-sided rings or fused ring systems. The method tolerated many chemical groups used in drug building. It also shortened routes to known medicines in demonstration runs. Atom deletion opens chemical territory that standard building steps skip. Precise oxygen spotting in crowded rings was the key hurdle cleared. Iodoform under light drives the oxygen-removal step in the scheme.
Catalog record
| CREATOR | Ying-Qi Zhang, Shuo-Han Li, Ming Joo Koh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |