Acute pretrauma ethanol exacerbates PTSD-like phenotype in rats and is reversed by early intranasal ketamine
Bar Eilat Yogev, Gal Levi, Noa Efroni, Amnon C Sintov, Doron Todder, Joseph Zohar, Hagit Cohen · 2026
Read Acute pretrauma ethanol exacerbates PTSD-like phenotype in rats and is reversed by early intranasal ketamine by Bar Eilat Yogev, Gal Levi, Noa Efroni, Amnon C Sintov, Doron Todder, Joseph Zohar, Hagit Cohen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13527053.txt.
Description
Bar Eilat Yogev and colleagues test, in a 2026 rat study, whether drinking alcohol shortly before a traumatic event worsens later post-traumatic stress symptoms, and whether early ketamine can reverse that effect. Alcohol use before trauma is common yet understudied as a risk factor. Rats received ethanol or saline before a predator scent stress exposure.
Timing mattered. Ethanol given four hours before stress, but not thirty minutes before, raised the share of rats showing a PTSD-like pattern a week later and deepened shrinkage of dendrites in a hippocampal region. Combined exposure lowered two protective molecules, raised a channel protein, and erased a neuropeptide receptor signal. A single early nasal dose of ketamine in lipid vesicles after stress reduced fear freezing and dendritic loss, giving a more resilient profile.
Catalog record
| CREATOR | Bar Eilat Yogev, Gal Levi, Noa Efroni, Amnon C Sintov, Doron Todder, Joseph Zohar, Hagit Cohen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43649 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |