Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría · 2026
Read Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines by Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13527045.txt.
Description
Paz Cartas-Cejudo and co-authors study, in twenty twenty-six, the sense-of-smell pathway in Parkinson's disease, and test a drug that may shield brain cells from its toxic protein. Parkinson's involves clumps of a protein, alpha-synuclein, and loss of dopamine neurons. The team profiled proteins in the olfactory tract, an early affected region, from seventeen controls and twenty-one patients. Damage to protein housekeeping grew with disease stage, and the protein's interaction network shifted progressively. A computer drug-repurposing search then ranked candidates that might restore the altered profiles.
A top hit was pyroxamide, a blocker of an enzyme called HDAC1. In cell tests, the drug reduced damage from alpha-synuclein fibrils across three cell types: nasal lining cells, immune microglia, and dopamine neurons.
Catalog record
| CREATOR | Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |