Schistosomiasis vaccine SchistoShield® induces functional immune memory responses in US and African populations
Mumtaz Y. Balkhi, Aravindan Kalyanasundaram, Aryandra Arya, Desalegn W. Kifle, Mallory Mckinnon, Dinesh Krishnappa, Harshvardhan Shrivastava, Mohamadou Siribie, Asma Aziz, Hyonjin Jeon, Tanyada Yongchaitrakul, Birkneh T. Tadesse, Njariharinjakamampionona Rakotozandrindrainy, Ravomialisoa Razafimanan · 2026
Read Schistosomiasis vaccine SchistoShield® induces functional immune memory responses in US and African populations by Mumtaz Y. Balkhi, Aravindan Kalyanasundaram, Aryandra Arya, Desalegn W. Kifle, Mallory Mckinnon, Dinesh Krishnappa, Harshvardhan Shrivastava, Mohamadou Siribie, Asma Aziz, Hyonjin Jeon, Tanyada Yongchaitrakul, Birkneh T. Tadesse, Njariharinjakamampionona Rakotozandrindrainy, Ravomialisoa Razafimanan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13526879.txt.
Description
Mumtaz Y Balkhi and colleagues showed that the SchistoShield vaccine triggers lasting immune memory in people on two continents. Published in 2026, the study examined blood cells from United States and African trial volunteers who had received the Sm-p80 plus GLA-SE vaccine. It targets schistosomiasis, a worm disease infecting about 250 million people. Recall tests re-exposed immune cells to the vaccine antigen in the lab.
Vaccinated volunteers produced strong effector and memory T-cell responses, releasing a broad mix of signaling proteins and killer molecules. Antibody-secreting cells specific to the antigen also appeared in volunteers followed over time. The authors read these hallmarks as signs of a potentially effective vaccine, building on earlier safety trials in the United States, Madagascar, and Burkina Faso. Readers get immunological backing for a vaccine aimed at a major neglected disease.
Catalog record
| CREATOR | Mumtaz Y. Balkhi, Aravindan Kalyanasundaram, Aryandra Arya, Desalegn W. Kifle, Mallory Mckinnon, Dinesh Krishnappa, Harshvardhan Shrivastava, Mohamadou Siribie, Asma Aziz, Hyonjin Jeon, Tanyada Yongchaitrakul, Birkneh T. Tadesse, Njariharinjakamampionona Rakotozandrindrainy, Ravomialisoa Razafimanan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |