Characterization of liver disease regression in murine models of liver fibrosis and portal hypertension
Philipp Königshofer, Ksenia Brusilovskaya, Benedikt S. Hofer, Oleksandr Petrenko, Benedikt Simbrunner, Katharina Bareiner, Kerstin Zinober, Katharina Regnat, Vlad Taru, Thomas Sorz-Nechay, Katharina Bonitz, Hubert Scharnagl, Tatjana Stojakovic, Michael Trauner, Stefan G. Kauschke, Larissa Pfisterer, Philipp Schwabl, Thomas Reiberger · 2026
Read Characterization of liver disease regression in murine models of liver fibrosis and portal hypertension by Philipp Königshofer, Ksenia Brusilovskaya, Benedikt S. Hofer, Oleksandr Petrenko, Benedikt Simbrunner, Katharina Bareiner, Kerstin Zinober, Katharina Regnat, Vlad Taru, Thomas Sorz-Nechay, Katharina Bonitz, Hubert Scharnagl, Tatjana Stojakovic, Michael Trauner, Stefan G. Kauschke, Larissa Pfisterer, Philipp Schwabl, Thomas Reiberger (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13526872.txt.
Description
Philipp Königshofer leads a large team in a 2026 mouse study mapping how liver disease regresses after toxin exposure ends, seeking a clean window for testing future anti-fibrotic drugs. Two standard toxins, thioacetamide and carbon tetrachloride, were given for eight or twelve weeks, then withdrawn for one or two weeks of recovery.
Diseased animals showed clear scarring and raised portal pressure against healthy controls. After withdrawal, scar area fell significantly in some models within one week and in nearly all by two weeks, while portal pressure regressed across all models by two weeks. Liver enzymes normalized quickly, and fibrosis genes declined gradually. The harshest model, twelve weeks of carbon tetrachloride, kept elevated scarring and pressure even after recovery, which the authors qualify as the best regression test bed.
Catalog record
| CREATOR | Philipp Königshofer, Ksenia Brusilovskaya, Benedikt S. Hofer, Oleksandr Petrenko, Benedikt Simbrunner, Katharina Bareiner, Kerstin Zinober, Katharina Regnat, Vlad Taru, Thomas Sorz-Nechay, Katharina Bonitz, Hubert Scharnagl, Tatjana Stojakovic, Michael Trauner, Stefan G. Kauschke, Larissa Pfisterer, Philipp Schwabl, Thomas Reiberger |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38918 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |