New hybrid pyridine–1,2,4-triazole scaffolds: synthesis, in vitro evaluation of anticancer and antimicrobial activity, and in silico insights
Aida Šermukšnytė, Dainius Lukauskas, Maryna Stasevych, Viktor Zvarych, Olena Komarovska-Porokhnyavets, Kristina Kantminienė, Ingrida Tumosienė, Vilma Petrikaitė · 2026
Read New hybrid pyridine–1,2,4-triazole scaffolds: synthesis, in vitro evaluation of anticancer and antimicrobial activity, and in silico insights by Aida Šermukšnytė, Dainius Lukauskas, Maryna Stasevych, Viktor Zvarych, Olena Komarovska-Porokhnyavets, Kristina Kantminienė, Ingrida Tumosienė, Vilma Petrikaitė (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13526864.txt.
Description
Aida Šermukšnytė and colleagues synthesized hybrid pyridine-triazole compounds and tested them against cancer and microbes. Published in 2026, the study built triazole-thiol derivatives and screened them in cell monolayers and 3D tumor spheroids against lung, triple-negative breast, and melanoma cell lines. New cancer drugs and new antimicrobials are both urgently needed as resistance grows.
Compounds with a dibromopyridyl fragment proved most toxic to cancer cells, and compound 34 led the set, killing all three lines at low micromolar doses. In spheroids, compound 34 slowed growth of breast and melanoma models, while two others cut viability without shrinking size. Compound 26 also beat a standard antifungal and matched a standard antibacterial in lab tests. Computer docking hinted at MEK and BRAF targets, awaiting lab confirmation.
Catalog record
| CREATOR | Aida Šermukšnytė, Dainius Lukauskas, Maryna Stasevych, Viktor Zvarych, Olena Komarovska-Porokhnyavets, Kristina Kantminienė, Ingrida Tumosienė, Vilma Petrikaitė |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |