Unlocking Lewis acid–free metalation of O–nucleophiles in HFIP
Kacper Łyczek, Martyna Markwitz, Maciej Janicki, Krzysztof Kuciński · 2026
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Description
Kacper Łyczek and colleagues found a way to attach silicon groups to oxygen compounds without any acid catalyst. Published in 2026, the chemistry paper shows that hexafluoroisopropanol, a solvent prized for steadying charged forms, lets allylsilanes tag alcohols and silanols gently. Older routes to silyl ethers, siloxanes, and borasiloxanes generally demanded strong Lewis or Brønsted acids.
The new method covers many alcohols and silanols with high yields, avoiding harsh steps and corrosive waste. Tagging matters because it shields oxygen groups and adds silicon handles used to build complex molecules. The authors frame the solvent itself as the enabler, opening cleaner routes to shielded building blocks. Readers get a practical advance for synthesis labs, with solvent green credentials still to weigh.
Catalog record
| CREATOR | Kacper Łyczek, Martyna Markwitz, Maciej Janicki, Krzysztof Kuciński |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |