A pathogenic CD8⁺ TRM–chemokine axis orchestrates liver fibrosis and provides circulating biomarkers during chronic Clonorchis sinensis infection
Xinyue Du, Jiashun Li, Xin Wang, Wenyu Wu, Tingjun Zhu, Huibo Yan, Chenyun Wu, Yuanyuan Li, Yuwei Gao, Haibo Yi, Kokouvi Kassegne, Xiangwei Li, Xiaoyin Niu, Helena Helmby, Samuel C. Wassmer, Youqiong Ye, Banchob Sripa, Guangjie Chen, Menbao Qian, Zhaojun Wang · 2026
Read A pathogenic CD8⁺ TRM–chemokine axis orchestrates liver fibrosis and provides circulating biomarkers during chronic Clonorchis sinensis infection by Xinyue Du, Jiashun Li, Xin Wang, Wenyu Wu, Tingjun Zhu, Huibo Yan, Chenyun Wu, Yuanyuan Li, Yuwei Gao, Haibo Yi, Kokouvi Kassegne, Xiangwei Li, Xiaoyin Niu, Helena Helmby, Samuel C. Wassmer, Youqiong Ye, Banchob Sripa, Guangjie Chen, Menbao Qian, Zhaojun Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13526845.txt.
Description
Du and colleagues report a 2026 study of how chronic liver fluke infection scars the liver, using the fluke Clonorchis sinensis in mice. The team mapped immune cells in the liver over the course of chronic infection.
A population of resident memory CD8 T cells built up in the liver and drove the damage. These cells release chemokines, signal proteins that call in more immune cells and switch on scar-forming fibroblasts. Removing CD8 T cells at set phases clearly eased inflammation and scarring, proving their causal role. One chemokine, CCL4, mostly from these cells, tracked fibrosis severity in mice and in patient samples. A blood marker that mirrors liver scarring could let doctors monitor this infection without biopsies.
Catalog record
| CREATOR | Xinyue Du, Jiashun Li, Xin Wang, Wenyu Wu, Tingjun Zhu, Huibo Yan, Chenyun Wu, Yuanyuan Li, Yuwei Gao, Haibo Yi, Kokouvi Kassegne, Xiangwei Li, Xiaoyin Niu, Helena Helmby, Samuel C. Wassmer, Youqiong Ye, Banchob Sripa, Guangjie Chen, Menbao Qian, Zhaojun Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |