ERAD-level gene switches for on-demand protein secretion and rapidly controlled gene therapies
Ting Gao, Shichao Li, Yuxuan Fan, Wenyi Yan, Minghui He, Qihao Zhang, Yilin Li, Qi Liu, Pengli Wang, Jian Jiang, Lihang Zhang, Yuting Zhou, Liuqi Zhao, Qiqi Xiong, Yuhang Wu, Sichen Yuan, Shaocong Fang, Hongyun Tang, Martin Fussenegger, Hui Wang, Jiawei Shao, Mingqi Xie · 2026
Read ERAD-level gene switches for on-demand protein secretion and rapidly controlled gene therapies by Ting Gao, Shichao Li, Yuxuan Fan, Wenyi Yan, Minghui He, Qihao Zhang, Yilin Li, Qi Liu, Pengli Wang, Jian Jiang, Lihang Zhang, Yuting Zhou, Liuqi Zhao, Qiqi Xiong, Yuhang Wu, Sichen Yuan, Shaocong Fang, Hongyun Tang, Martin Fussenegger, Hui Wang, Jiawei Shao, Mingqi Xie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13526830.txt.
Description
Gao and colleagues published a 2026 study on gene switches that release medicine on demand. Gene therapies often run at one fixed level once delivered. The team built switches from a cell system that tags proteins for disposal. A licensed pill, taken by mouth, pauses the disposal and frees the protein.
With disposal paused, therapeutic proteins poured into the blood of treated mice. The release was tunable by dose and reversed when pills stopped. The design rode along with standard virus delivery used in gene therapy. The team showed uses for heart disease and chronic pain control. Simple parts, they argue, beat complex circuits for clinic-ready control. Remote control like this could steady hormone or pain treatments.
Catalog record
| CREATOR | Ting Gao, Shichao Li, Yuxuan Fan, Wenyi Yan, Minghui He, Qihao Zhang, Yilin Li, Qi Liu, Pengli Wang, Jian Jiang, Lihang Zhang, Yuting Zhou, Liuqi Zhao, Qiqi Xiong, Yuhang Wu, Sichen Yuan, Shaocong Fang, Hongyun Tang, Martin Fussenegger, Hui Wang, Jiawei Shao, Mingqi Xie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |