Frontotemporal dementia associated CHCHD10V57E mutation aggravates tau pathology via disrupting the CHCHD10-Rab7A-TBC1D15 complex
Jie Sheng, Jing Yan, Yan Xu, Xingyu Xu, Xuemei Zhang, Anqi Wang, Buhui Liu, Jun Ma, Xiuying Duan, Heng Zhou, Wei Liu · 2026
Read Frontotemporal dementia associated CHCHD10V57E mutation aggravates tau pathology via disrupting the CHCHD10-Rab7A-TBC1D15 complex by Jie Sheng, Jing Yan, Yan Xu, Xingyu Xu, Xuemei Zhang, Anqi Wang, Buhui Liu, Jun Ma, Xiuying Duan, Heng Zhou, Wei Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13526787.txt.
Description
Jie Sheng and others show, in a 2026 study, that a frontotemporal dementia mutation in a mitochondrial protein worsens tau disease through a trafficking complex. Frontotemporal dementia strikes thinking early, and the CHCHD10 V57E variant emerged from patients, yet its effect on tau driven disease was unknown. Fly and cell models carrying human tau were built.
The mutation worsened eye damage and climbing defects, and cut lifespan in flies carrying tau. In lab cells it damaged synapse health, raised output of total and modified tau, and lifted toxicity. Modified tau piled up inside the cell's endosomal recycling system. Draining a trafficking protein called Rab7A partly undid the harm. Deeper work showed the normal protein complex holds Rab7A idle, while the mutant breaks the complex and frees Rab7A to act.
Catalog record
| CREATOR | Jie Sheng, Jing Yan, Yan Xu, Xingyu Xu, Xuemei Zhang, Anqi Wang, Buhui Liu, Jun Ma, Xiuying Duan, Heng Zhou, Wei Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 99095 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |