Activation of the Reverse Cholesterol Transport Pathway: A Strategy to Ameliorate Lipid Metabolic Dyshomeostasis in the Microenvironment Following Spinal Cord Injury
Xiaoxin Wang, Guina Tan, Ru Feng, Min Ni, Feng Gao, Jianjun Li · 2026
Read Activation of the Reverse Cholesterol Transport Pathway: A Strategy to Ameliorate Lipid Metabolic Dyshomeostasis in the Microenvironment Following Spinal Cord Injury by Xiaoxin Wang, Guina Tan, Ru Feng, Min Ni, Feng Gao, Jianjun Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13526753.txt.
Description
Xiaoxin Wang and colleagues study, in a 2026 mouse investigation, why lipid handling fails after spinal cord injury and whether a drug can restart cholesterol clearance. Injury releases masses of myelin lipid, turning macrophages into foam cells that sustain inflammation and block repair. Reverse cholesterol transport normally ships such lipid out, yet its behavior at the lesion was unclear.
In a mid-back contusion model, two transport components rose persistently, but one sat mainly in astrocytes rather than macrophages. A third component, ABCG1, fell at protein level despite rising message, a bottleneck favoring foam cells. An LXR-activating drug raised the first component, partly restored the third, cut foam-cell accumulation, lowered an inflammatory signal, and improved movement scores. Full restoration eluded the drug, pointing to protein instability as the next target.
Catalog record
| CREATOR | Xiaoxin Wang, Guina Tan, Ru Feng, Min Ni, Feng Gao, Jianjun Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45667 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |