DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang · 2026
Read DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma by Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13526706.txt.
Description
Xuanxuan Li and co-authors trace how a chemical tag on a key energy enzyme helps lung tumors grow and resist a copper-based form of cell death. Tumors rewire their energy systems as they turn malignant, and tags added to proteins after they are built help drive that rewiring. The role of one tag, called succinylation, on this enzyme was unclear.
Mapping the tags in lung tumor tissue showed one spot on the enzyme carried far more of the tag than normal. That tag, placed by another enzyme, changes how the energy enzyme works. In turn it shifts the cell's power production and its balance of harmful oxygen byproducts. Blocking that pathway could make tumors easier to kill.
Catalog record
| CREATOR | Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |