Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species
Rajnish Ranjan, Emmanuelle Logette, Mirjia Herzog, Valerie Buchillier, Enrico Scantamburlo, Henry Markram · 2026
Read Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species by Rajnish Ranjan, Emmanuelle Logette, Mirjia Herzog, Valerie Buchillier, Enrico Scantamburlo, Henry Markram (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13526694.txt.
Description
The channels that set the heartbeat's rhythm also speed up and slow down with temperature. Rajnish Ranjan and co-authors measure that dependence properly for the first time. They used stable cell lines and automated patch-clamp rigs. Mouse, rat, and human versions of the HCN channel family were recorded under identical conditions. Temperatures and drug treatments varied in a controlled way.
One family member, HCN3, produced no measurable current on its own. It may need partner factors to work. The others kept a steady speed ranking, with HCN1 fastest and HCN4 slowest. Warmth sped every channel's gating. Responses to a natural modulator and a blocking drug measured reproducibly too. The full dataset is public. It gives modelers and experimenters a shared reference for how these channels behave.
Catalog record
| CREATOR | Rajnish Ranjan, Emmanuelle Logette, Mirjia Herzog, Valerie Buchillier, Enrico Scantamburlo, Henry Markram |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |