Immune reset: what do we learn from bone marrow transplantation
Huidong Guo, Xiao-Jun Huang · 2026
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Description
Huidong Guo and Xiao-Jun Huang review, in a 2026 paper, bone marrow transplantation as an immune reset rather than simple cell replacement. Transplantation has long been framed as a cure for blood cancers through swapping a diseased blood-forming system for a healthy donor one. The authors argue the process runs deeper, collapsing and rebuilding immunity itself.
After transplant, immunity does not return to its former state. Instead it settles at a new equilibrium shaped by conditioning injury, donor-recipient immune interactions, regrowth of supporting stroma, and ongoing treatments. The review gathers evidence on how tolerance is reinstalled and stability maintained under those forces. By treating transplantation as a human model of immune reprogramming, the authors extract principles that may guide therapies for autoimmunity, immune aging, and other immune diseases.
Catalog record
| CREATOR | Huidong Guo, Xiao-Jun Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49455 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |