AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu · 2026
Read AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer by Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13526531.txt.
Description
Qin Yuan and co-authors trace how a protein called AARS1 helps bladder cancer grow, spread, and come back after treatment. They found the protein at high levels in tumor tissue, especially in cancers that invade muscle or return, and patients with more of it fared worse. In lab and animal tests, the protein pushed cells to divide, invade, resist death, and seed growths in the lung. It did so by boosting a growth pathway, raising sugar burning, and making more lactate.
Lactate changed a chemical tag on the cell's DNA packaging at the switch for a sugar-burning gene, turning that gene on more strongly. Blocking the gene weakened the cancer traits, which supports the chain the team describes. A search for drugs that bind the protein turned up eltrombopag, a drug in use for other care, and it slowed tumors in early models.
Catalog record
| CREATOR | Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |