Abatacept for steroid-refractory fulminant immune checkpoint inhibitor myocarditis with triple M overlap syndrome: a case report with serial endomyocardial biopsy assessment
Ruriko Matsui, Kimi Sato, Kazuko Tajiri, Tomoko Ishizu, Giacomo Tini Melato, Linda Piras, Deepti Ranganathan · 2026
Read Abatacept for steroid-refractory fulminant immune checkpoint inhibitor myocarditis with triple M overlap syndrome: a case report with serial endomyocardial biopsy assessment by Ruriko Matsui, Kimi Sato, Kazuko Tajiri, Tomoko Ishizu, Giacomo Tini Melato, Linda Piras, Deepti Ranganathan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13526244.txt.
Description
Ruriko Matsui and co-authors published this case report in 2026. It tells of a man in his sixties whose cancer immunotherapy triggered a rare triple attack: inflammation of the heart muscle, of skeletal muscle, and of the nerve-muscle junction. This overlap syndrome is often fatal.
Two checkpoint drugs had treated his returning lung cancer. Steroids and antibody infusions failed to stop the heart damage; his heart's pumping share fell to twenty-three percent and dangerous rhythms struck. A heart tissue sample showed killer T cells flooding the muscle. The team added abatacept, a drug that calms T cells, and repeated it as repeat biopsies showed lingering inflammation. His heart recovered to fifty-six percent pumping share, and a late biopsy showed marked healing. The authors credit biopsy-guided dosing for the save.
Catalog record
| CREATOR | Ruriko Matsui, Kimi Sato, Kazuko Tajiri, Tomoko Ishizu, Giacomo Tini Melato, Linda Piras, Deepti Ranganathan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |