Continuous infusion [11C]-(+)-PHNO PET for measuring dopamine D2/3 receptor availability and amphetamine effects across the brain: Feasibility and test-retest reliability
Irena Dajic, Ulrich Sauerzopf, Ana Weidenauer, Cornelia Diendorfer, Katharina Landesmann, Ivo Rausch, Andreas Hahn, Benjamin Spurny-Dworak, Manfred Klöbl, Murray Reed, Rupert Lanzenberger, Martin Bauer, Markus Zeitlinger, Lucie Bartova, Martin Wolkersdorfer, Lukas Nics, Wolfgang Wadsak, Marcus Hacker, Cécile Philippe, Nicole Praschak-Rieder, Matthäus Willeit · 2026
Read Continuous infusion [11C]-(+)-PHNO PET for measuring dopamine D2/3 receptor availability and amphetamine effects across the brain: Feasibility and test-retest reliability by Irena Dajic, Ulrich Sauerzopf, Ana Weidenauer, Cornelia Diendorfer, Katharina Landesmann, Ivo Rausch, Andreas Hahn, Benjamin Spurny-Dworak, Manfred Klöbl, Murray Reed, Rupert Lanzenberger, Martin Bauer, Markus Zeitlinger, Lucie Bartova, Martin Wolkersdorfer, Lukas Nics, Wolfgang Wadsak, Marcus Hacker, Cécile Philippe, Nicole Praschak-Rieder, Matthäus Willeit (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13526102.txt.
Description
Irena Dajic leads a large Vienna team in a 2026 feasibility study of a steady-infusion PET method for measuring dopamine D2 and D3 receptors across the whole brain at once. These receptors sit in both deep and cortical regions, and quantifying them together with one tracer has been difficult. The tracer used, PHNO, prefers these receptor types.
Five healthy men each underwent two scans using a bolus plus constant infusion design, with an intravenous amphetamine challenge midway to displace the tracer. Baseline binding values were reproducible for most regions, with test-retest variation under ten percent. Amphetamine lowered binding in cortical and several deep regions in both scans. Two dopamine-rich areas had not reached equilibrium before the challenge, so the authors recommend protocol refinement there.
Catalog record
| CREATOR | Irena Dajic, Ulrich Sauerzopf, Ana Weidenauer, Cornelia Diendorfer, Katharina Landesmann, Ivo Rausch, Andreas Hahn, Benjamin Spurny-Dworak, Manfred Klöbl, Murray Reed, Rupert Lanzenberger, Martin Bauer, Markus Zeitlinger, Lucie Bartova, Martin Wolkersdorfer, Lukas Nics, Wolfgang Wadsak, Marcus Hacker, Cécile Philippe, Nicole Praschak-Rieder, Matthäus Willeit |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38206 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |