First-in-human EphA2-targeting PET imaging with the bicyclic radiotracer [68Ga]Ga-BCY18469 in pancreatic cancer patients: biodistribution, dosimetry and initial findings
Ann-Christin Eder, Christoph-Ferdinand Wielenberg, Mohamed Aymen Omrane, Aikaterini Klotsotyra, Katia Brüggemann, Mohamed El Fakiri, Heiko Becker, Michael Quante, Michael Mix, Matthias Eder, Philipp T. Meyer, Martin T. Freitag · 2026
Read First-in-human EphA2-targeting PET imaging with the bicyclic radiotracer [68Ga]Ga-BCY18469 in pancreatic cancer patients: biodistribution, dosimetry and initial findings by Ann-Christin Eder, Christoph-Ferdinand Wielenberg, Mohamed Aymen Omrane, Aikaterini Klotsotyra, Katia Brüggemann, Mohamed El Fakiri, Heiko Becker, Michael Quante, Michael Mix, Matthias Eder, Philipp T. Meyer, Martin T. Freitag (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13525963.txt.
Description
Ann-Christin Eder and colleagues report a 2026 first-in-human imaging study of a radioactive tracer targeting EphA2, a receptor overproduced in pancreatic cancer and linked with poor prognosis. No suitable tracer for clinical scans had existed. The bicyclic peptide tracer, labeled with gallium-68, was tested in patients with confirmed pancreatic ductal adenocarcinoma.
Seven patients, five after chemotherapy and two at first staging, underwent PET and CT imaging at several time points after injection. No adverse events occurred, kidneys took the highest absorbed dose, and overall radiation exposure was modest. Tumor uptake was rapid, within fifteen minutes, with mainly kidney excretion. Of forty-five lesions, the new scan flagged thirty-six and found eleven that standard imaging missed, while missing nine that standard imaging caught. The authors support further study.
Catalog record
| CREATOR | Ann-Christin Eder, Christoph-Ferdinand Wielenberg, Mohamed Aymen Omrane, Aikaterini Klotsotyra, Katia Brüggemann, Mohamed El Fakiri, Heiko Becker, Michael Quante, Michael Mix, Matthias Eder, Philipp T. Meyer, Martin T. Freitag |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35424 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |