Exosome-delivered pepDCBLD2 promotes glucose metabolism to induce chemoresistance in colon cancer
Xinyi Wang, Jiayu Yang, Haiou Yang, Yue Xu, Huiya Wang, Mengyu Sun, Ming Gao, Ye Wang, Haiyang Zhang · 2026
Read Exosome-delivered pepDCBLD2 promotes glucose metabolism to induce chemoresistance in colon cancer by Xinyi Wang, Jiayu Yang, Haiou Yang, Yue Xu, Huiya Wang, Mengyu Sun, Ming Gao, Ye Wang, Haiyang Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13525674.txt.
Description
Xinyi Wang and colleagues report a two thousand twenty-six study of a tiny protein shipped between colon cancer cells that spreads drug resistance. The standard drug oxaliplatin often fails as resistance grows. Some circular RNAs unexpectedly encode small proteins with real jobs.
One circular RNA produced a small protein through rolling translation. That protein shielded a growth gene from destruction, raising its output. Resistant cells packaged the protein into exosomes and sent it to sensitive neighbours. Recipient cells then burned more glucose and resisted the drug. Blocking this courier system could resensitize tumours.
Catalog record
| CREATOR | Xinyi Wang, Jiayu Yang, Haiou Yang, Yue Xu, Huiya Wang, Mengyu Sun, Ming Gao, Ye Wang, Haiyang Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |