Identifying risk factors for adverse drug reactions in HIV/AIDS patients using LASSO regression modeling
Shiqiong Huang, Liang Gong, Hui Qi, Guoqiang Zhou, Ji Sun · 2026
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Description
Shiqiong Huang and colleagues run a 2026 retrospective study of adverse drug reactions among hospitalized patients with HIV and AIDS in China, using a variable-selection regression method to hunt for risk factors. Such reactions add heavily to hospital burden in this population. Suspected reactions were judged for causality with an international monitoring system.
Among 918 patients, 210 experienced a reaction, an incidence of 22.88 percent. Blood and lymphatic disorders were the commonest manifestation class. Antibacterial drugs caused the largest share, followed closely by antivirals. The selection model singled out one clear factor, the number of medications given during hospitalization, which raised the odds of a reaction substantially. The authors propose the count as a simple flag for closer monitoring and regimen review.
Catalog record
| CREATOR | Shiqiong Huang, Liang Gong, Hui Qi, Guoqiang Zhou, Ji Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27555 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |