Association of Vitamin D Deficiency With Cardiometabolic and Renal Outcomes in Patients With Autoimmune Rheumatic Diseases: A Systematic Review and Meta-Analysis
Adnan Imran, Hafiz Abdul Waris, Sikander Khan Tanoli, Muhammad Tabish Raza, Kamran Memon, Hassan Saeed · 2026
Read Association of Vitamin D Deficiency With Cardiometabolic and Renal Outcomes in Patients With Autoimmune Rheumatic Diseases: A Systematic Review and Meta-Analysis by Adnan Imran, Hafiz Abdul Waris, Sikander Khan Tanoli, Muhammad Tabish Raza, Kamran Memon, Hassan Saeed (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13525189.txt.
Description
Adnan Imran and colleagues pool, in a 2026 systematic review and meta-analysis, evidence linking vitamin D deficiency with heart, metabolic, and kidney outcomes in autoimmune rheumatic diseases. These chronic immune diseases carry extra cardiovascular and renal burden, and vitamin D deficiency is common within them. Searches covered five databases through March 2026 without language limits.
Eighteen observational studies qualified, with four independent cohorts feeding at least one pooled analysis. Deficiency was associated with roughly double the all-cause mortality hazard. The cardiovascular event estimate was large but imprecise, and the link between vitamin D level and protein in the urine in children with lupus was inconclusive. Other metabolic and vascular studies pointed adverse but could not be pooled because measures differed. The authors flag confounding and varied definitions.
Catalog record
| CREATOR | Adnan Imran, Hafiz Abdul Waris, Sikander Khan Tanoli, Muhammad Tabish Raza, Kamran Memon, Hassan Saeed |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |