Olfactory bulb 6-OHDA neurotoxicity as a model of early cortical dysfunction
Edson Fiorenza-Neto, Bruna B. Gattiboni, Karin Almeida, Luis F. Marqueze, Bassam F. Mogharbel, Juliana R. N. de Aguiar, Larissa C. Marques, Larissa R. Lazarini, Stephanie R. S. Carvalhal, Angelica Boldt, Ricardo C. Cunha, Katherine A. T. Carvalho, Anand Thirupathi, Zsolt Radak, Ricardo A. Pinho · 2026
Read Olfactory bulb 6-OHDA neurotoxicity as a model of early cortical dysfunction by Edson Fiorenza-Neto, Bruna B. Gattiboni, Karin Almeida, Luis F. Marqueze, Bassam F. Mogharbel, Juliana R. N. de Aguiar, Larissa C. Marques, Larissa R. Lazarini, Stephanie R. S. Carvalhal, Angelica Boldt, Ricardo C. Cunha, Katherine A. T. Carvalho, Anand Thirupathi, Zsolt Radak, Ricardo A. Pinho (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13524966.txt.
Description
Edson Fiorenza-Neto leads a large team in a 2026 rat study testing whether damaging the olfactory bulb with a neurotoxin can model early cortical dysfunction seen before motor Parkinson's disease. The smell bulb is among the first regions affected in neurodegeneration and connects widely to cortex and limbic areas. The toxin 6-OHDA was injected into the left bulb.
Twelve days after surgery, lesioned animals showed altered exploration in an open field, spending more time in the center. Cortical tissue showed higher IL-6, lower interferon gamma, and unchanged levels of several other immune signals. Oxidative damage markers rose, while antioxidant enzyme activity and three neuronal signaling genes stayed unchanged. The authors argue a local bulb lesion alone can trigger behavioral, inflammatory, and oxidative change in connected cortex.
Catalog record
| CREATOR | Edson Fiorenza-Neto, Bruna B. Gattiboni, Karin Almeida, Luis F. Marqueze, Bassam F. Mogharbel, Juliana R. N. de Aguiar, Larissa C. Marques, Larissa R. Lazarini, Stephanie R. S. Carvalhal, Angelica Boldt, Ricardo C. Cunha, Katherine A. T. Carvalho, Anand Thirupathi, Zsolt Radak, Ricardo A. Pinho |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35174 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |