Discovery of Ro 41‐0960, a Non‐Steroidal Inhibitor of the Na+/K+‐ATPase
Carlos Cruz‐Cortés, Jaroslava Šeflová, Guadalupe Guerrero‐Serna, Eric N Jimenez‐Vazquez, Justus Anumonwo, L Michel Espinoza‐Fonseca · 2026
Read Discovery of Ro 41‐0960, a Non‐Steroidal Inhibitor of the Na+/K+‐ATPase by Carlos Cruz‐Cortés, Jaroslava Šeflová, Guadalupe Guerrero‐Serna, Eric N Jimenez‐Vazquez, Justus Anumonwo, L Michel Espinoza‐Fonseca (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13524838.txt.
Description
Carlos Cruz-Cortés and co-authors reported in 2026 the discovery of a new blocker of a key cell pump. The pump, called Na+/K+-ATPase, controls ion balance in heart cells and is a proven target in heart failure. Steroid drugs that act on it work but carry a narrow safety margin and can disturb heart rhythm. The team identified a non-steroidal compound, Ro 41-0960, that inhibits the pump in a different way.
Tests on purified enzyme and cell preparations measured its strength. Docking and molecular dynamics studies suggested it can reach two sites on the pump, though simple competition with ATP did not explain the data. It barely affected a related pump, SERCA, and left electrical signals in human heart cells unchanged at strong doses. The work offers a fresh scaffold for safer heart drugs.
Catalog record
| CREATOR | Carlos Cruz‐Cortés, Jaroslava Šeflová, Guadalupe Guerrero‐Serna, Eric N Jimenez‐Vazquez, Justus Anumonwo, L Michel Espinoza‐Fonseca |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |