CLEC-1 promotes early IFN response in cDC1s and favors immune dysregulation during sepsis in mice
Thomas Teja Ogor, Esther Porée, Javier Saenz, Marion Davieau, Victor Gourain, Camille Ligeron, Florian Pierre Martin, Cynthia Fourgeux, Claire Chédeville, Julie Mignon, Martin Braud, Aurélie Moreau, Régis Josien, Aurore Morello, Etienne Foucher, Nicolas Poirier, Jeremie Poschmann, Antoine Roquilly, · 2026
Read CLEC-1 promotes early IFN response in cDC1s and favors immune dysregulation during sepsis in mice by Thomas Teja Ogor, Esther Porée, Javier Saenz, Marion Davieau, Victor Gourain, Camille Ligeron, Florian Pierre Martin, Cynthia Fourgeux, Claire Chédeville, Julie Mignon, Martin Braud, Aurélie Moreau, Régis Josien, Aurore Morello, Etienne Foucher, Nicolas Poirier, Jeremie Poschmann, Antoine Roquilly, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13524758.txt.
Description
Thomas Teja Ogor and co-authors study a surface receptor called CLEC-1 and its role in sepsis, in a mouse study from 2026. Sepsis is organ failure driven by a badly skewed immune response to infection. The receptor sits mainly on a lung cell type that helps start immune defenses.
Mice lacking the receptor gene recovered better after infection with Escherichia coli bacteria. Without it, lung defense cells made a weaker early interferon response, less of a signal that draws in monocytes, and fewer of those cells arrived. The mice also showed stronger antigen display and less immune shutdown at a later infection. Blocking the human form of the receptor with an antibody calmed excess inflammation in mice carrying the human gene. The authors name the receptor as a possible drug target.
Catalog record
| CREATOR | Thomas Teja Ogor, Esther Porée, Javier Saenz, Marion Davieau, Victor Gourain, Camille Ligeron, Florian Pierre Martin, Cynthia Fourgeux, Claire Chédeville, Julie Mignon, Martin Braud, Aurélie Moreau, Régis Josien, Aurore Morello, Etienne Foucher, Nicolas Poirier, Jeremie Poschmann, Antoine Roquilly, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |