Rapamycin Attenuates Acute Pancreatitis-Induced Acinar Injury in Mice With Pancreatic Loss of Gα13
Hidayatullah G Munshi, Anastasia E Metropulos, Khadijeh Karbalaei, Christina Spaulding, Nida Mubin, Yaning Xi, Apurba Majumder, Thao D Pham, Mario A Shields · 2026
Read Rapamycin Attenuates Acute Pancreatitis-Induced Acinar Injury in Mice With Pancreatic Loss of Gα13 by Hidayatullah G Munshi, Anastasia E Metropulos, Khadijeh Karbalaei, Christina Spaulding, Nida Mubin, Yaning Xi, Apurba Majumder, Thao D Pham, Mario A Shields (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13524613.txt.
Description
Munshi and colleagues studied in 2026 the protein Gα13, a signal relay inside cells, in pancreatitis, the painful inflammation of the pancreas. Samples from people with acute and chronic pancreatitis showed lower levels of this protein. The team then triggered pancreatitis in mice with a standard drug, comparing normal mice with mice whose pancreas lacked the protein, and added rapamycin, a drug that blocks the growth pathway mTOR.
Munshi found that mice without the pancreatic protein suffered worse injury to the enzyme-making acinar cells in both acute and chronic disease. Inflammation rose only mildly, and only in the chronic form. Loss of the protein also raised mTOR signalling. Rapamycin softened the acute injury in these mice but made chronic disease worse, a split result. The authors conclude Gα13 normally protects the pancreas, and mTOR blockade helps only in the acute setting.
Catalog record
| CREATOR | Hidayatullah G Munshi, Anastasia E Metropulos, Khadijeh Karbalaei, Christina Spaulding, Nida Mubin, Yaning Xi, Apurba Majumder, Thao D Pham, Mario A Shields |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |