Identification, validation, and prediction of longitudinal recovery phenotypes in degenerative cervical myelopathy: analysis of prospective cohorts and a randomised controlled trial

Karlo M. Pedro, Mohammed Ali Alvi, Christopher Lozano, Vishwathsen Karthikeyan, Alex B. Bak, Benjamin M. Davies, James S. Harrop, Jetan H. Badhiwala, Jefferson R. Wilson, Wendy Lou, Zihang Lu, Kevin E. Thorpe, Michael G. Fehlings · 2026

Read Identification, validation, and prediction of longitudinal recovery phenotypes in degenerative cervical myelopathy: analysis of prospective cohorts and a randomised controlled trial by Karlo M. Pedro, Mohammed Ali Alvi, Christopher Lozano, Vishwathsen Karthikeyan, Alex B. Bak, Benjamin M. Davies, James S. Harrop, Jetan H. Badhiwala, Jefferson R. Wilson, Wendy Lou, Zihang Lu, Kevin E. Thorpe, Michael G. Fehlings (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13524543.txt.

Description

Karlo Pedro and a large team sort patients with a worn neck spine into recovery types in a 2026 study. The condition squeezes the spinal cord and causes clumsy hands, weak legs, and poor balance. Doctors have long graded it by nerve damage alone, but experts now say it shifts across nerve, function, and life quality measures at once.

The team mined three past data sets: two large clinic cohorts from North America and abroad, plus one randomized trial, together spanning 2005 to 2017. They looked for groups of patients whose three kinds of scores moved together in distinct ways over time. They then checked that the groups held up in fresh data and built a tool to predict each new patient’s likely type. Such types could help set honest hopes after surgery.

Catalog record

CREATORKarlo M. Pedro, Mohammed Ali Alvi, Christopher Lozano, Vishwathsen Karthikeyan, Alex B. Bak, Benjamin M. Davies, James S. Harrop, Jetan H. Badhiwala, Jefferson R. Wilson, Wendy Lou, Zihang Lu, Kevin E. Thorpe, Michael G. Fehlings
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE46 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13524543

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