Nucleoside drives the self-assembly and enables delivery of phosphate containing therapeutics
Jiamin Yao, Liu Liu, Junfeng Wang, Kaichao Wang, Jiang Liu, Yao Yuan, Hang Zhao · 2026
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Description
A peer-reviewed research article from Europe PMC (2026). Nucleobase driven molecular recognition has enabled the self-assembly of a wide range of nucleosides and nucleotides. Emerging evidence suggests that ribose actively influences the nucleoside self-assembly process; however, how ribose associated chemical features contribute to this process remains unclear. Here, we propose a previously underexplored nucleoside phosphate recognition model in which the ribose 5′-OH group likely participates in hydrogen bonding with phosphate moieties, assisted by electrostatic pre-organization through protonation deprotonation equilibria.
Catalog record
| CREATOR | Jiamin Yao, Liu Liu, Junfeng Wang, Kaichao Wang, Jiang Liu, Yao Yuan, Hang Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |