Recombinant human adenovirus type 5-vectored vaccine expressing avian reovirus σC protein protects against prevalent genotype I avian reovirus in chickens
Xiyao Cui, Zhenrui Song, Defang Zhou, Liangyu Yang, Hongbo Chen, Hui Zhang, Ziqiang Cheng · 2026
Read Recombinant human adenovirus type 5-vectored vaccine expressing avian reovirus σC protein protects against prevalent genotype I avian reovirus in chickens by Xiyao Cui, Zhenrui Song, Defang Zhou, Liangyu Yang, Hongbo Chen, Hui Zhang, Ziqiang Cheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13524466.txt.
Description
Xiyao Cui and colleagues report a 2026 vaccine study against avian reovirus, a poultry virus causing arthritis, gut disease, and immune suppression with heavy economic losses. Older vaccines based on the S1133 strain protect poorly against current variants. The team built a vaccine using a human adenovirus vector carrying the viral sigma C protein, the main target of neutralizing antibodies.
The construct expressed the protein stably across thirteen passages in the laboratory. One-day-old specific-pathogen-free chickens receiving the vaccine produced strong antibody responses within a week, plus higher levels of two immune signaling molecules, showing both antibody and cellular activation. After challenge with a prevalent field strain, protection reached 86 percent, with reduced shedding, lower tissue virus loads, and milder organ damage than in unvaccinated controls.
Catalog record
| CREATOR | Xiyao Cui, Zhenrui Song, Defang Zhou, Liangyu Yang, Hongbo Chen, Hui Zhang, Ziqiang Cheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |