Protein farnesylation: from molecular mechanisms to therapeutic targeting in cancer, aging, and beyond
Jiacheng Lou, Danlu Zhang, Yingjie Wang · 2026
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Description
Jiacheng Lou and co-authors review protein farnesylation in a 2026 paper on a lipid tag that controls where proteins sit and act. An enzyme adds a fifteen-carbon lipid to the tail of key proteins, from Ras switches to nuclear lamins.
The review covers how the enzyme picks targets and how later steps trim the tag. Blocking the enzyme drew fame as a cancer idea, though some Ras forms escape by a backup route. The blockers do help in blood cancers and in progeria, a fast-aging disease. New dual blockers and related routes widen the field. Readers get a full tour from basic chemistry to drug hopes.
Catalog record
| CREATOR | Jiacheng Lou, Danlu Zhang, Yingjie Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 130 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |