Caveolin 1 is a conserved host factor mediating Bacillus cereus hemolysin BL toxin cytolytic toxicity
Yingying Lu, Jie Liu, Chengyu Liu, Zehua Zuo, Michael Ewing, Hang Chen, Toren Finkel, Stephen H. Leppla, Shihui Liu, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez · 2026
Read Caveolin 1 is a conserved host factor mediating Bacillus cereus hemolysin BL toxin cytolytic toxicity by Yingying Lu, Jie Liu, Chengyu Liu, Zehua Zuo, Michael Ewing, Hang Chen, Toren Finkel, Stephen H. Leppla, Shihui Liu, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13524335.txt.
Description
Yingying Lu and colleagues identify, in a 2026 study, caveolin-1 as a third host factor needed for a Bacillus cereus toxin to kill cells. Hemolysin BL is a three-part pore-forming toxin and a major cause of this bacterium's harm in food poisoning and severe infection. Two host receptors were already known, yet mice lacking both stayed only partly protected.
Genome-wide CRISPR knockout screens in mouse and human cells pointed to caveolin-1, a membrane protein tied to tiny surface pockets called caveolae. Imaging and binding tests showed the protein sits with the toxin at the cell surface and physically associates with it. Mice missing all three factors were completely resistant to toxin challenge. The authors define a three-part host system and propose caveolin-1 as a determinant of susceptibility.
Catalog record
| CREATOR | Yingying Lu, Jie Liu, Chengyu Liu, Zehua Zuo, Michael Ewing, Hang Chen, Toren Finkel, Stephen H. Leppla, Shihui Liu, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 100 KB |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |