BCR::ABL1 e1a2 (p190)-Positive Myeloid Blast Neoplasm: Diagnostic Challenges in Distinguishing De Novo Acute Myeloid Leukemia From Previously Unrecognized Chronic Myeloid Leukemia in the Blast Phase
Valeria González Quiroz, Raul Sergio Campillo González, Jorge Alberto Garay Hernandez, Guadalupe de los Angeles Salazar Gonzalez, Cesar Fabian Vallejo Rico · 2026
Read BCR::ABL1 e1a2 (p190)-Positive Myeloid Blast Neoplasm: Diagnostic Challenges in Distinguishing De Novo Acute Myeloid Leukemia From Previously Unrecognized Chronic Myeloid Leukemia in the Blast Phase by Valeria González Quiroz, Raul Sergio Campillo González, Jorge Alberto Garay Hernandez, Guadalupe de los Angeles Salazar Gonzalez, Cesar Fabian Vallejo Rico (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13524208.txt.
Description
Valeria González Quiroz and colleagues present a 2026 case that shows how a rare leukemia fusion can hide a diagnosis. Chronic myeloid leukemia is usually driven by the BCR::ABL1 fusion making a p210 protein. The variant in this patient made the smaller p190 form, more typical of a different leukemia, and standard tests missed it.
A 48-year-old woman with two years of unexplained anemia showed blood and marrow packed with maturing myeloid cells and 35 percent blasts carrying myeloid markers. Her chromosome study looked normal, while a targeted probe found the fusion and a qualitative test identified the rare e1a2 transcript after the usual quantitative test returned negative. She received acute leukemia induction chemotherapy. The authors stress that atypical features should prompt broader molecular testing.
Catalog record
| CREATOR | Valeria González Quiroz, Raul Sergio Campillo González, Jorge Alberto Garay Hernandez, Guadalupe de los Angeles Salazar Gonzalez, Cesar Fabian Vallejo Rico |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |