Antifibrotic monocyte activation by nanoparticles resolves murine pulmonary fibrosis
Hannah Viola, Hannah Carter, Kate Griffin, Rita Medina Costa, Riley McDonald, Brennan Callow, Francina Gonzalez de Los Santos, Peyton Panovich, Sean Carey, Marisa Martinez, Ryan Chen, Zharia Hunter, Alexandra Piotrowski-Daspit, Gary Luker, Bethany B Moore, Lonnie Shea · 2026
Read Antifibrotic monocyte activation by nanoparticles resolves murine pulmonary fibrosis by Hannah Viola, Hannah Carter, Kate Griffin, Rita Medina Costa, Riley McDonald, Brennan Callow, Francina Gonzalez de Los Santos, Peyton Panovich, Sean Carey, Marisa Martinez, Ryan Chen, Zharia Hunter, Alexandra Piotrowski-Daspit, Gary Luker, Bethany B Moore, Lonnie Shea (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13524071.txt.
Description
Hannah Viola leads a large team in a 2026 study showing that empty nanoparticles can resolve lung fibrosis in mice by reprogramming immune cells. Fibrosis burdens many organs and has few treatments. Innate immune cells can drive scarring, yet they also help dissolve it, and the team tested whether degradable particles could switch monocytes toward repair.
Particles made of a biodegradable polymer, carrying no drug cargo, shifted profibrotic macrophages in culture toward antifibrotic activity, altered their energy use, and raised enzymes that break down collagen and related matrix. Given intravenously, the particles resolved established bleomycin-induced lung scarring and reversed the direction of over a thousand genes. Treated lungs showed less profibrotic signaling, more repair pathways, and greater monocyte recruitment, supporting materials-based immune therapy.
Catalog record
| CREATOR | Hannah Viola, Hannah Carter, Kate Griffin, Rita Medina Costa, Riley McDonald, Brennan Callow, Francina Gonzalez de Los Santos, Peyton Panovich, Sean Carey, Marisa Martinez, Ryan Chen, Zharia Hunter, Alexandra Piotrowski-Daspit, Gary Luker, Bethany B Moore, Lonnie Shea |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47240 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |