Genotypes, Fluconazole Tolerance and Virulence Phenotypes of Candida albicans Bloodstream Isolates: A Multilocus Sequence Typing‐Based Analysis
Shang‐Yi Lin, Yin‐Tse Huang, Ho‐Yin Huang, Wei‐Chun Hung, Yi‐Ting Tseng, Po‐Liang Lu · 2026
Read Genotypes, Fluconazole Tolerance and Virulence Phenotypes of Candida albicans Bloodstream Isolates: A Multilocus Sequence Typing‐Based Analysis by Shang‐Yi Lin, Yin‐Tse Huang, Ho‐Yin Huang, Wei‐Chun Hung, Yi‐Ting Tseng, Po‐Liang Lu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13523731.txt.
Description
Shang-Yi Lin and five colleagues analyze fluconazole tolerance in Candida albicans bloodstream isolates from Taiwan, in a study from twenty twenty-six. Tolerance is an emerging phenotype in these infections, distinct from outright resistance. Its links to genetic lineages and virulence traits were unclear. The team typed isolates from three hospitals in southern Taiwan.
One hundred seventy-nine isolates were profiled for tolerance, biofilm biomass, and enzyme activity. Genetic typing found one hundred sixty-nine unique sequence types across fourteen clades. High tolerance was spread broadly across diverse lineages. One clade stood out with higher tolerance and biofilm formation. Statistical analysis tied high tolerance to that clade and to protease activity, not biofilm biomass. Tolerance, the authors show, is a lineage-spanning trait with specific hotspots.
Catalog record
| CREATOR | Shang‐Yi Lin, Yin‐Tse Huang, Ho‐Yin Huang, Wei‐Chun Hung, Yi‐Ting Tseng, Po‐Liang Lu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |