Photoinduced Reductive Elimination from Sulfur Enables a Unique Synthetic Valorization of Sulfonamides
Jaxon L. Barney, Bhargav Patel, Santino M. Servagno, Alexander J. Reif, Somnath Das, Wyatt A. Gibbs, Brian J. Levandowski, Mrinmoy Das, Elvira R. Sayfutyarova, Bryan Kudisch, Michael D. VanHeyst, Eric D. Nacsa · 2026
Read Photoinduced Reductive Elimination from Sulfur Enables a Unique Synthetic Valorization of Sulfonamides by Jaxon L. Barney, Bhargav Patel, Santino M. Servagno, Alexander J. Reif, Somnath Das, Wyatt A. Gibbs, Brian J. Levandowski, Mrinmoy Das, Elvira R. Sayfutyarova, Bryan Kudisch, Michael D. VanHeyst, Eric D. Nacsa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13523703.txt.
Description
Barney and a team in the United States found in 2026 a light driven way to turn sulfonamides, a vast class of drug like compounds, into fresh goods. Drug firms hold hoards of these sulfur builds, yet most known tricks keep the sulfur group, which caps what can be made. Their method shines light on the build and cuts the sulfur out.
A wide set of ring sulfonamides with choice side groups came out the other side as anilines, a prized drug frame in their own right. Probes of the path point to a rare swap: in the lit state, a ring slides from sulfur to nitrogen as the bond breaks. A twin polar path, through a reshaped form of the start build, runs as a small side road. The authors pitch the find as a key to locked hoards.
Catalog record
| CREATOR | Jaxon L. Barney, Bhargav Patel, Santino M. Servagno, Alexander J. Reif, Somnath Das, Wyatt A. Gibbs, Brian J. Levandowski, Mrinmoy Das, Elvira R. Sayfutyarova, Bryan Kudisch, Michael D. VanHeyst, Eric D. Nacsa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |