The anti-inflammatory potential of nicotinamide (vitamin B3) in JIA: modulating Treg numbers and function with nicotinamide
Lotte Nijhuis, Rianne C Scholman, Arief Lalmohamed, Sebastiaan J Vastert, Jorg van Loosdregt · 2026
Read The anti-inflammatory potential of nicotinamide (vitamin B3) in JIA: modulating Treg numbers and function with nicotinamide by Lotte Nijhuis, Rianne C Scholman, Arief Lalmohamed, Sebastiaan J Vastert, Jorg van Loosdregt (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13523523.txt.
Description
Lotte Nijhuis and colleagues investigate, in a 2026 study, whether nicotinamide, a form of vitamin B3, can calm inflammation in juvenile idiopathic arthritis, the most common rheumatic disease of childhood. The disease involves chronic joint inflammation with an imbalance between regulatory T cells, which restrain immunity, and effector T cells. Nicotinamide helps make a molecule central to cell energy and immune control.
In laboratory work, nicotinamide raised the share of regulatory-type T cells in blood and joint fluid cells from patients and increased suppressive capacity in healthy control cells. In a small pilot phase, six patients took high-dose nicotinamide by mouth for three days, and similar levels appeared in blood plasma and joint fluid, showing the vitamin reaches inflamed joints. The authors call for larger studies on dose and long-term place in care.
Catalog record
| CREATOR | Lotte Nijhuis, Rianne C Scholman, Arief Lalmohamed, Sebastiaan J Vastert, Jorg van Loosdregt |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28976 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |